Research

instruments for fall risk

Effects of inactivity or exercise on neuroplasticity in Parkinson’s disease

2009 freezing

2008 freezing

Updating this page will be ongoing. Periodically I plan to post current research on a particular topic related to Parkinson’s disease. The hyperlinks above enables you to download the reference list.

You can view abstracts by clicking on the specific references below.

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Determining fall risk in people with PD is not a simple task and is typically multifactoral. More recently the Functional Gait Assessment Tool is showing to be a good instrument in helping to determine fall risk.

Foreman, K. B., O. Addison, et al. (epub 2011) “Testing balance and fall risk in persons with Parkinson disease, an argument for ecologically valid testing.” Parkinsonism Relat Disord 17(3): 166-71.
Huang, S. L., C. L. Hsieh, et al. (epub 2010) “Minimal detectable change of the timed “up & go” test and the dynamic gait index in people with Parkinson disease.” Phys Ther 91(1): 114-21.
Jenkins, M. E., A. M. Johnson, et al. (epub 2010) “Predictive validity of the UPDRS postural stability score and the Functional Reach Test, when compared with ecologically valid reaching tasks.” Parkinsonism Relat Disord 16(6): 409-11.
Leddy, A. L., B. E. Crowner, et al. (epub 2010)”Functional gait assessment and balance evaluation system test: reliability, validity, sensitivity, and specificity for identifying individuals with Parkinson disease who fall.” Phys Ther 91(1): 102-13.
Qutubuddin, A. A., P. O. Pegg, et al. (2005). “Validating the Berg Balance Scale for patients with Parkinson’s disease: a key to rehabilitation evaluation.” Arch Phys Med Rehabil 86(4): 789-92.
Steffen, T. and M. Seney (2008). “Test-retest reliability and minimal detectable change on balance and ambulation tests, the 36-item short-form health survey, and the unified Parkinson disease rating scale in people with parkinsonism.” Phys Ther 88(6): 733-46.
Latt, M. D., S. R. Lord, et al. (2009). “Clinical and physiological assessments for elucidating falls risk in Parkinson’s disease.” Mov Disord 24(9): 1280-9.

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    From inactivity to exercise, how does this effect the basal ganglia?

Dibble, L. E., T. F. Hale, et al. (2009). “High intensity eccentric resistance training decreases bradykinesia and improves Quality Of Life in persons with Parkinson’s disease: a preliminary study.” Parkinsonism Relat Disord 15(10): 752-7.

Fisher, B. E., A. D. Wu, et al. (2008). “The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson’s disease.” Arch Phys Med Rehabil 89(7): 1221-9.

Gerecke, K. M., Y. Jiao, et al. (epub 2010)”Exercise protects against MPTP-induced neurotoxicity in mice.” Brain Res.

Hirsch, M. A. (2009). “Community-based rehabilitation for Parkinson’s disease: from neurons to neighborhoods.” Parkinsonism Relat Disord 15 Suppl 3: S114-7.

Hirsch, M. A. and B. G. Farley (2009). “Exercise and neuroplasticity in persons living with Parkinson’s disease.” Eur J Phys Rehabil Med 45(2): 215-29.

King, L. A. and F. B. Horak (2009). “Delaying mobility disability in people with Parkinson disease using a sensorimotor agility exercise program.” Phys Ther 89(4): 384-93.

Petzinger, G. M., B. E. Fisher, et al. (2010) “Enhancing neuroplasticity in the basal ganglia: the role of exercise in Parkinson’s disease.” Mov Disord 25 Suppl 1: S141-5.

Ridgel, A. L., J. L. Vitek, et al. (2009). “Forced, not voluntary, exercise improves motor function in Parkinson’s disease patients.” Neurorehabil Neural Repair 23(6): 600-8.

Tajiri, N., T. Yasuhara, et al. (2010)”Exercise exerts neuroprotective effects on Parkinson’s disease model of rats.” Brain Res 1310: 200-7.

VanLeeuwen, J. E., G. M. Petzinger, et al. (epub 2009)”Altered AMPA receptor expression with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury.” J Neurosci Res 88(3): 650-68.

Villar-Cheda, B., D. Sousa-Ribeiro, et al. (2009). “Aging and sedentarism decrease vascularization and VEGF levels in the rat substantia nigra. Implications for Parkinson’s disease.” J Cereb Blood Flow Metab 29(2): 230-4.

Zigmond, M. J., J. L. Cameron, et al. (2009). “Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency.” Parkinsonism Relat Disord 15 Suppl 3: S42-5.

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    What’s new in 2009 ‘freezing’ research?

Almeida, Q. J. and C. A. Lebold (2009). “Freezing of gait in parkinson’s disease: a perceptual cause for a motor impairment?” J Neurol Neurosurg Psychiatry.

Baechlin, M., M. Plotnik, et al. (2009). “Assistive cueing, context awareness, freezing of gait, Parkinson disease, personal health assistant.” IEEE Trans Inf Technol Biomed.

Chee, R., A. Murphy, et al. (2009). “Gait freezing in Parkinson’s disease and the stride length sequence effect interaction.” Brain 132(Pt 8): 2151-60.

Devos, D., R. Bordet, et al. (2009). “[Pharmacological hypotheses and therapeutic strategies for gait disorders in Parkinson's disease.].” Rev Neurol (Paris).

Ferraye, M. U., B. Debu, et al. (2009). “[Deep brain stimulation and gait disorders in Parkinson disease.].” Rev Neurol (Paris).

Frazzitta, G., R. Maestri, et al. (2009). “Rehabilitation treatment of gait in patients with Parkinson’s disease with freezing: a comparison between two physical therapy protocols using visual and auditory cues with or without treadmill training.” Mov Disord 24(8): 1139-43.

Giladi, N., J. Tal, et al. (2009). “Validation of the freezing of gait questionnaire in patients with Parkinson’s disease.” Mov Disord 24(5): 655-61.

Hackney, M. E. and G. M. Earhart (2009). “The Effects of a Secondary Task on Forward and Backward Walking in Parkinson’s Disease.” Neurorehabil Neural Repair.

Jacobs, J. V., J. G. Nutt, et al. (2009). “Knee trembling during freezing of gait represents multiple anticipatory postural adjustments.” Exp Neurol 215(2): 334-41.

Jovanov, E., E. Wang, et al. (2009). “deFOG – A real time system for detection and unfreezing of gait of Parkinson’s patients.” Conf Proc IEEE Eng Med Biol Soc 1: 5151-4.

Latt, M. D., S. R. Lord, et al. (2009). “Clinical and physiological assessments for elucidating falls risk in Parkinson’s disease.” Mov Disord 24(9): 1280-9.

Lewis, S. J. and R. A. Barker (2009). “A pathophysiological model of freezing of gait in Parkinson’s disease.” Parkinsonism Relat Disord 15(5): 333-8.

Mancini, M., C. Zampieri, et al. (2009). “Anticipatory postural adjustments prior to step initiation are hypometric in untreated Parkinson’s disease: an accelerometer-based approach.” Eur J Neurol 16(9): 1028-34.

Nieuwboer, A., K. Baker, et al. (2009). “The short-term effects of different cueing modalities on turn speed in people with Parkinson’s disease.” Neurorehabil Neural Repair 23(8): 831-6.

Nieuwboer, A., L. Rochester, et al. (2009). “Reliability of the new freezing of gait questionnaire: agreement between patients with Parkinson’s disease and their carers.” Gait Posture 30(4): 459-63.

Nieuwboer, A., S. Vercruysse, et al. (2009). “Upper limb movement interruptions are correlated to freezing of gait in Parkinson’s disease.” Eur J Neurosci 29(7): 1422-30.

Park, H. K., J. S. Kim, et al. (2009). “Functional brain imaging in pure akinesia with gait freezing: [18F] FDG PET and [18F] FP-CIT PET analyses.” Mov Disord 24(2): 237-45.

Schroeteler, F., K. Ziegler, et al. (2009). “[Freezing of gait : phenomenology, pathophysiology, and therapeutic approaches].” Nervenarzt 80(6): 693-9.

Snijders, A. H., V. Weerdesteyn, et al. (2009). “Obstacle avoidance to elicit freezing of gait during treadmill walking.” Mov Disord 25(1): 57-63.